Photodynamische TherapiePhotodynamische Desinfektion
|
Photomedicine and Laser Surgery, Volume 27,
Number 2, 2009
Case Report
Photodynamic Therapy Can Be Effective as
a Treatment for Herpes Simplex Labialis
Juliana Marotti, D.D.S.,1 Ana Cecília Correa
Aranha, D.D.S., Ms.C., Ph.D.,2, Carlos De Paula Eduardo,
D.D.S., Ms.C., Ph.D.,2 and Martha Simões Ribeiro, Ph.D.3
Abstract
Background Data and Objective:
Herpes is a common
infectious disease that is caused by human herpesviruses.
Several treatments have been proposed, but none of them
prevent reactivation of the virus. This article describes
the use of photodynamic therapy (PDT) as a treatment for
herpes lesions, and reports on four cases.
Materials and Methods: PDT was used
as an adjuvant therapy for the treatment of herpes labialis
in four patients. A special type of 0.01% (m/V) of methylene
blue solution was applied to the vesicular stage of
herpesviral disease and the lesions were irradiated with
laser energy (wavelength 660 nm, energy density 120 J/cm2,
output power of 40 mW, 2 min per point, 4.8 J of
energy/point, at four points). After 24 h the patients
returned and phototherapy was repeated with the same
equipment, this time with 3.8 J/cm2 and 15 mW, for a total
dose of 0.6 J. The same procedure was repeated 72 h and 1 wk
later.
Results: Treatment with low-level
laser therapy can be considered as an option in the
treatment of herpes labialis, and decreases the frequency of
vesicle recurrence and provides comfort for patients. No
significant acute side effects were noted and the lesions
healed rapidly.
Conclusion: Treatment of herpes
labialis with PDT was effective, had no side effects, and
when associated with laser phototherapy, accelerated the
healing process.
|
